Table 2.
UTMOST Single tissue analysis (Non Brain tisues).
| Loci | Location hg19 | MinP (UTMOST) | Tissue | Z score | SNPs in model | Other associations GWAS, GBA and/or TWAS |
|---|---|---|---|---|---|---|
| NKX2-2* | chr20:21491660-21494664 | 5.28 × 10−6 | Colon transverse | −4.55 | 2 | Grove et al./Alonso-Gonzalez et al. |
| MANBA | chr4:103552643-103682151 | 3.2 × 10−6 | Esophagus muscularis | 4.66 | 47 | – |
| ERI1* | chr8:8860314-8890849 | 3.84 × 10−6 | Esophagus muscularis | 4.62 | 124 | – |
| DOK5 | chr20:53092266-53267710 | 4.86 × 10−7 | Liver | −409.74 | 4 | – |
| ATXN1 | chr6:16299343-16761721 | 2.4 × 10−6 | Nerve tibial | −4.72 | 27 | – |
| FERMT2 | chr14:53323989-53417815 | 3.1 × 10−6 | Skin not sun exposed | −5.49 | 14 | – |
| MITF | chr3:69788586-70017488 | 2.34 × 10−6 | Stomach | 4.72 | 111 | – |
| CTSB | chr8:11700034-11725646 | 3.36 × 10−6 | Thyroid | 4.65 | 66 | – |
| ANGEL1 | chr14:77253586-77279283 | 1.89 × 10−6 | Uterus | 4.76 | 83 | – |
List of independent significant loci.
Bonferroni threshold = 3.42 × 10−6.
Genes in bold are associated within gastrointestinal tissues.
GWAS genome-wide association study, SNP single nucleotide polymorphism, TWAS transcriptome-wide association study.
*Marginally significant.