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Concentration–responses of aristolactam derivatives on the inhibition of Tat-induced HIV-1 transcription.
| Compound | IC50 (μmol/L)a |
|---|---|
| 1 | 1.11 ± 0.02 |
| 2 | 2.85 ± 0.17 |
| 3 | 2.58 ± 0.05 |
| 4 | 3.40 ± 0.02 |
| 5 | 1.36 ± 0.01 |
| 6 | 2.47 ± 0.26 |
| 7 | 1.78 ± 0.15 |
| 8 | 2.25 ± 0.24 |
| 9 | 3.38 ± 0.05 |
| Seliciclib | 2.25 ± 0.14 |
aThe compounds were assessed in bl-DTR cells using a concentration–response test.
