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. 2021 Apr 30;12(5):433. doi: 10.1038/s41419-021-03719-3

Fig. 3. POU2F2 regulates glycolytic reprogramming in GBM cells.

Fig. 3

A GSEA showed significant enrichment of gene sets involved in the glucose import in B Cell lymphoma cells, shPOU2F2 compared with shPOU2F2/POU2F2. B Glucose uptake of GBM cells with or without POU2F2 silence and restoration of POU2F2. C Glucose consumption of GBM cells with or without POU2F2 silence and restoration of POU2F2. D Lactate production of GBM cells with or without POU2F2 silence and restoration of POU2F2. E Lactate dehydrogenase activities of GBM cells with or without POU2F2 silence and restoration of POU2F2. F Glycolytic flux changes of LN229 and U-118 cells. ECAR extracellular acidification rate. G Quantitative RT-PCR analysis of key glycolysis-associated enzymes levels in LN229 cells with or without POU2F2 silence and restoration of POU2F2. All data were shown as the mean ± SD, **p < 0.01.