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. 2021 Apr 30;11:9387. doi: 10.1038/s41598-021-88625-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Compatibility of alternate swab media with the point-of-care test. The M1 Sample Prep Cartridge Kit for RNA 2.0 was used to extract 200 ul of swabs sample from Bartels (A), Cobas (B), and eSwabs (≤ 200 µl) (C). SARS-CoV-2 was detected in 6 of 7 Bartels swabs, 10 of 11 e-Swabs, and 8 of 11 Cobas swabs. Paired t-tests comparing the Cq values of the Franklin with the Ct values of the clinical lab test detecting the same targets showed there was no significant difference between the Cq and Ct values for any swab when Ct was detected by the Franklin three9 thermocycler (p_B = 0.2864, p_C = 0.6566, and p_E = 0.0601). p_B p value of Bartels swab; p_C p value of Cobas swab; p_E p value of e-swab swab.