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. 2021 Apr 30;11:9362. doi: 10.1038/s41598-021-88703-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Combinatorial effect of trametinib and cediranib on SVR xenografts. Two treatment experiments were performed with different endpoints. In one experiment (left, A,B) all tumors were harvested at the same timepoint to allow for comparison of tumor weight between groups. In the second (right, C,D), tumors were harvested after they grew above the IACUC mandated maximum size or became ulcerated. (A) Combined treatment with trametinib and cediranib resulted in decreased tumor weight. (B) Representative tumors after 17 days of treatment. (C) Tumor growth curves of SVR xenografts treated with vehicle, trametinib, cediranib, or cediranib combined with trametinib in a separate experiment in which trametinib and combination treated mice were allowed to grow after control and cediranib treated mice were sacrificed. Curves discontinue when any mice from the representative group had to be sacrificed. (D) Representative mice from each group (two representative pictures from each group) demonstrating tumor hemorrhage in the control and cediranib groups and not in the trametinib treated groups. Data are presented ± SEM. Graphs were made in GraphPad Prism 7 (https://www.graphpad.com/scientific-software/prism/). Unedited/cropped images were formatted in Adobe Photoshop 2020 (https://www.adobe.com/) to create the figure layout.