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. 2021 Apr 30;11:9362. doi: 10.1038/s41598-021-88703-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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RNA sequencing of SVR xenograft whole lysate after treatment. (A) Principal component analysis demonstrates 3 distinct patterns of expression, with control (blue) and cediranib (red) treated tumors in one cluster, and trametinib treated tumors (purple) and combined trametinib and cediranib treated tumors (green) clustering separately. (B–D) Volcano plots for cediranib (B), trametinib (C), and combination (D) treated tumors compared to controls vehicle treated tumors. (E) Volcano plot comparing trametinib treated tumors to combination treated tumors. (F) Gene sets enriched in trametinib treated tumors compared with combination treated tumors. Volcano plots were made in R (https://www.r-project.org/). Graphs in panel (F) were made with GSEA software

available at https://www.gsea-msigdb.org/gsea/index.jsp.