Figure 5.

The effect of progesterone and progesterone receptor antagonist on intracranial pressure and cerebral perfusion pressure before and after the brain trauma (n=6 rats per group). Every bar represents mean±SEM. A. ^*** P<0.001 at 1, 4, 24 and 48 hr compared with sham group; ^### P<0.001 at 4, 24, and 48 hr compared with oil group. B. ^† P<0.05 at 4 hr, and ^††† P<0.001 at 24, and 48 hr compared with VEH + P4 group. C. ^***P<0.001 at 1, 4, 24, and 48 hr compared with sham group; ^### P<0.001 at 4, 24, and 48 hr compared with oil group; D. ^†† P<0. 01 at 24, and ^††† P<0.001 48 hr compared with VEH + P4 group

VEH: Vehicle; P4: Progesterone; RU + P4: RU486 + progesterone; TBI: Traumatic brain injury