TABLE A1.
The discriminative species of the gut DNA virome among the young, adult, and old groups
| Species | Family | Relative abundance | p‐value | LDA | Enrichment | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Young (mean) | Young (SD) | Adult (mean) | Adult (SD) | Old (mean) | Old (SD) | |||||
| Enterococcus phage phiEF24C | Myoviridae | 1.8E‐04 | 1.7E‐04 | 2.0E‐05 | 1.8E‐05 | 3.9E‐05 | 4.7E‐05 | 0.015 | 2.124 | Young |
| Vibrio phage VP882 | Myoviridae | 3.3E‐05 | 2.1E‐05 | 9.3E‐06 | 2.1E‐05 | 0.0E+00 | 0.0E+00 | 0.008 | 2.383 | Young |
| Enterobacteria phage IME10 | Podoviridae | 2.2E‐05 | 1.8E‐05 | 1.6E‐05 | 1.1E‐05 | 0.0E+00 | 0.0E+00 | 0.029 | 2.888 | Young |
| Sinorhizobium phage phiM9 | Myoviridae | 2.2E‐03 | 1.4E‐03 | 2.1E‐04 | 2.4E‐04 | 5.0E‐04 | 6.8E‐04 | 0.028 | 2.964 | Young |
| Lactococcus phage Tuc2009 | Siphoviridae | 8.3E‐04 | 8.2E‐04 | 1.4E‐05 | 1.9E‐05 | 4.1E‐06 | 8.2E‐06 | 0.041 | 2.594 | Young |
| Staphylococcus phage S25‐4 | Myoviridae | 3.3E‐04 | 5.8E‐05 | 2.1E‐05 | 1.2E‐05 | 0.0E+00 | 0.0E+00 | 0.002 | 2.806 | Young |
| Listeria phage P70 | Siphoviridae | 1.9E‐03 | 1.5E‐03 | 1.4E‐04 | 1.2E‐04 | 9.7E‐04 | 1.4E‐03 | 0.046 | 2.949 | Young |
| Salmonella phage SPN3US | Myoviridae | 2.2E‐05 | 2.3E‐05 | 1.7E‐06 | 3.7E‐06 | 1.6E‐06 | 3.1E‐06 | 0.047 | 2.644 | Young |
| Paramecium bursaria Chlorella virus NE‐JV‐1 | Phycodnaviridae | 4.5E‐05 | 4.5E‐05 | 6.7E‐06 | 1.5E‐05 | 0.0E+00 | 0.0E+00 | 0.023 | 2.563 | Young |
| Vibrio phage nt‐1 | Myoviridae | 1.4E‐03 | 1.3E‐03 | 1.1E‐04 | 1.1E‐04 | 2.0E‐05 | 2.6E‐05 | 0.016 | 2.866 | Young |
| Shigella phage Ag3 | Myoviridae | 5.4E‐04 | 3.2E‐04 | 8.3E‐05 | 8.8E‐05 | 1.8E‐04 | 1.8E‐04 | 0.034 | 2.505 | Young |
| Halocynthia phage JM‐2012 | Myoviridae | 1.2E‐04 | 1.0E‐04 | 1.1E‐05 | 1.2E‐05 | 0.0E+00 | 0.0E+00 | 0.020 | 2.097 | Young |
| Enterobacteria phage phi92 | Myoviridae | 2.1E‐04 | 1.2E‐04 | 4.6E‐05 | 5.2E‐05 | 1.5E‐05 | 1.5E‐05 | 0.016 | 2.312 | Young |
| Acanthocystis turfacea Chlorella virus NE‐JV‐2 | Phycodnaviridae | 4.4E‐04 | 5.5E‐04 | 0.0E+00 | 0.0E+00 | 1.6E‐06 | 3.1E‐06 | 0.011 | 2.387 | Young |
| Staphylococcus phage 812 | Myoviridae | 6.6E‐04 | 2.9E‐04 | 1.4E‐04 | 8.1E‐05 | 2.9E‐04 | 3.5E‐04 | 0.037 | 2.454 | Young |
| Synechococcus phage ACG 2014d | Myoviridae | 6.4E‐04 | 3.4E‐04 | 2.2E‐04 | 2.5E‐04 | 1.1E‐04 | 1.4E‐04 | 0.031 | 2.483 | Young |
| Erwinia phage phiEaH2 | Siphoviridae | 1.4E‐04 | 1.0E‐04 | 1.1E‐05 | 2.0E‐05 | 4.8E‐05 | 8.0E‐05 | 0.035 | 2.345 | Young |
| Salmonella phage Stitch | Siphoviridae | 4.6E‐04 | 2.9E‐04 | 7.8E‐05 | 7.7E‐05 | 1.3E‐04 | 1.1E‐04 | 0.032 | 2.336 | Young |
| Escherichia phage Akfv33 | Siphoviridae | 1.4E‐04 | 1.4E‐04 | 1.6E‐05 | 8.9E‐06 | 3.6E‐07 | 7.2E‐07 | 0.004 | 2.529 | Young |
| Mycobacterium phage Courthouse | Siphoviridae | 4.1E‐04 | 4.8E‐04 | 3.8E‐05 | 6.4E‐05 | 3.8E‐05 | 7.6E‐05 | 0.026 | 2.459 | Young |
| Staphylococcus phage GH15 | Myoviridae | 2.8E‐03 | 4.6E‐03 | 6.0E‐05 | 3.5E‐05 | 4.1E‐05 | 2.8E‐05 | 0.010 | 3.224 | Young |
| Cellulophaga phage phi19‐1 | Siphoviridae | 1.2E‐04 | 1.7E‐04 | 0.0E+00 | 0.0E+00 | 4.1E‐06 | 8.2E‐06 | 0.001 | 2.038 | Young |
| Lactobacillus phage Ldl1 | Siphoviridae | 1.5E‐03 | 8.3E‐04 | 2.0E‐04 | 1.3E‐04 | 7.6E‐04 | 9.4E‐04 | 0.022 | 2.803 | Young |
| Lactobacillus phage c5 | Siphoviridae | 8.0E‐04 | 5.3E‐04 | 2.3E‐04 | 2.0E‐04 | 2.3E‐04 | 1.8E‐04 | 0.020 | 2.518 | Young |
| Aeromonas phage Aes012 | Myoviridae | 1.9E‐04 | 2.0E‐04 | 3.7E‐05 | 8.1E‐05 | 0.0E+00 | 0.0E+00 | 0.031 | 2.346 | Young |
| Enterobacteria phage JSE | Myoviridae | 2.1E‐04 | 1.1E‐04 | 3.6E‐05 | 4.3E‐05 | 2.5E‐05 | 3.0E‐05 | 0.013 | 2.355 | Young |
| uncultured Mediterranean phage uvMED | unclassified Viruses | 4.2E‐02 | 2.1E‐02 | 1.0E‐02 | 6.7E‐03 | 3.5E‐02 | 3.2E‐02 | 0.029 | 4.202 | Young |
| Bacillus phage vB BhaS‐171 | unclassified Viruses | 1.8E‐03 | 4.7E‐04 | 2.5E‐04 | 1.9E‐04 | 4.7E‐04 | 4.4E‐04 | 0.009 | 2.906 | Young |
| Yersinia phage phiR1‐37 | Myoviridae | 2.2E‐03 | 1.0E‐03 | 5.3E‐04 | 5.0E‐04 | 8.6E‐04 | 6.0E‐04 | 0.041 | 2.898 | Young |
| Escherichia phage ECML‐117 | Myoviridae | 1.6E‐04 | 1.1E‐04 | 1.5E‐04 | 1.5E‐04 | 0.0E+00 | 0.0E+00 | 0.013 | 2.210 | Young |
| Pseudomonas phage EL | Myoviridae | 1.5E‐04 | 2.3E‐04 | 2.3E‐06 | 3.3E‐06 | 9.7E‐06 | 1.2E‐05 | 0.049 | 2.364 | Young |
| Streptococcus phage Dp‐1 | Siphoviridae | 7.3E‐03 | 3.5E‐03 | 2.8E‐03 | 3.3E‐03 | 8.8E‐04 | 4.2E‐04 | 0.033 | 3.526 | Young |
| Synechococcus phage S‐SKS1 | Siphoviridae | 1.3E‐03 | 1.5E‐03 | 2.0E‐04 | 1.3E‐04 | 1.2E‐03 | 1.3E‐03 | 0.025 | 2.749 | Young |
| Streptococcus phage Str‐PAP‐1 | Podoviridae | 4.5E‐04 | 2.4E‐04 | 6.0E‐04 | 8.7E‐04 | 5.4E‐05 | 5.3E‐05 | 0.028 | 2.504 | Adult |
| Campylobacter phage IBB35 | Myoviridae | 1.3E‐03 | 7.5E‐04 | 1.4E‐03 | 2.7E‐03 | 7.9E‐05 | 7.0E‐05 | 0.020 | 2.865 | Adult |
| Xylella phage Prado | Podoviridae | 9.4E‐06 | 5.9E‐06 | 5.0E‐05 | 6.8E‐05 | 0.0E+00 | 0.0E+00 | 0.042 | 3.018 | Adult |
| Aeromonas phage 31 | Myoviridae | 8.4E‐06 | 6.9E‐06 | 3.7E‐04 | 7.7E‐04 | 1.1E‐04 | 4.3E‐05 | 0.014 | 2.558 | Adult |
| Cellulophaga phage phi10‐1 | Siphoviridae | 0.0E+00 | 0.0E+00 | 2.1E‐04 | 4.1E‐04 | 3.5E‐05 | 7.0E‐05 | 0.029 | 2.248 | Adult |
| White spot syndrome virus | Nimaviridae | 3.2E‐06 | 6.4E‐06 | 3.0E‐04 | 4.5E‐04 | 1.6E‐05 | 2.0E‐05 | 0.042 | 2.430 | Adult |
| Staphylococcus phage SAP‐2 | Podoviridae | 6.3E‐03 | 5.0E‐03 | 6.4E‐03 | 8.3E‐03 | 4.4E‐04 | 8.1E‐04 | 0.035 | 3.472 | Adult |
| Vibrio phage VPMS1 | Podoviridae | 7.4E‐05 | 1.2E‐04 | 7.7E‐03 | 1.2E‐02 | 0.0E+00 | 0.0E+00 | 0.023 | 3.522 | Adult |
| Caulobacter phage CcrColossus | Siphoviridae | 8.5E‐05 | 7.5E‐05 | 1.3E‐04 | 2.4E‐04 | 9.5E‐04 | 7.9E‐04 | 0.020 | 2.728 | Old |
| Halovirus HGTV‐1 | unclassified Viruses | 3.6E‐04 | 5.5E‐04 | 4.3E‐06 | 7.1E‐06 | 7.2E‐04 | 1.1E‐03 | 0.050 | 2.381 | Old |
| Clostridium phage phiCP7R | Podoviridae | 1.6E‐03 | 1.0E‐03 | 1.5E‐04 | 1.5E‐04 | 1.7E‐03 | 2.4E‐03 | 0.042 | 2.884 | Old |
| Streptococcus phage phiNJ2 | Siphoviridae | 7.5E‐06 | 9.3E‐06 | 1.5E‐05 | 2.6E‐05 | 4.6E‐04 | 6.1E‐04 | 0.034 | 2.449 | Old |