FIGURE 4.

USP35 overexpression reduces erastin/RSL3‐triggered iron disturbance and ferroptosis. A,B, Lipid ROS generation and MDA levels in lung cancer cells (n = 6). C,F, Statistical data about the releases of arachidonic acid metabolites (5‐HETE, 11‐HETE, 12‐HETE, and 15‐HETE) in the cell culture medium using LC–MS/MS analysis (n = 6). G,H, GSH levels and GPX4 activities in H460 and H1299 cell lines (n = 6). I,J, Relative LIP and Fe²⁺ levels (n = 6). Data are shown as mean ± SD, *P < .05 versus the matched group. NS indicates no significance