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. 2021 May 1;22:32. doi: 10.1186/s12868-021-00631-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The behavior of wild-type (WT, blue) and Chd8^+/∆SL (Chd8^±, red) mice in the open field test and social avoidance test. a Cumulative heatmaps for Open field (b) and non-social object and social object phases of Social Avoidance task. c Distance traveled during the duration of Open Field test. d Immobility time during the duration of Open Field test. e Immobility time in the “non-social object” stage. f Immobility time in the “social object” stage. g Time spent in the center in the social-object stage. h Immobility time in the center in the social-object stage. Columns with different superscript letters (a, b) are significantly different at p < 0.05