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. 2021 May 1;12:257. doi: 10.1186/s13287-021-02287-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — hADSC-Exo enhance cutaneous wound healing in an in vivo mouse model. a The study protocol. b Representative photographs of full-thickness excision wounds treated with rhEGF (positive control), hADSC, or hADSC-Exo. hADSC-Exo were administered either by sm or sc for 12 days. c Quantitative analysis of wound healing in each group. d H&E staining of wounded skin sections in different groups at day 12 post-wounding. Scale bar = 250 μm. e Masson staining of wounded skin sections in different groups at day 12 post-wounding. Results are presented as mean ± standard error of the mean; n = 8 for each group. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 vs vehicle control group. sm smearing administration, sc subcutaneous administration