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. 2021 May 1;12:257. doi: 10.1186/s13287-021-02287-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Effect of hADSC-Exo treatment on wound healing in vivo mouse model in a dose-dependent manner. a Representative photographs of full-thickness excisional wounds treated with hADSC-Exo (Qd), hADSC-Exo (Bid), and hADSC-Exo (Tid). b Quantitative analysis of wound healing in each group. c Histological structure of wounded skin in different groups. Scale bar = 250 μm. d Representative photographs of CD31 and VEGF immunostaining. Scale bar = 200 μm. e Quantitative analysis of the number of mature blood vessels. f Representative photographs of Ki67, PCNA, and C-Caspase3 immunostaining. Scale bar = 200 μm. g Ki67, PCNA, and C-Caspase3 expression of IHC-positive staining analyzed by mean percentage (±SEM). h Representative photographs of CD14, CD19, CD68, MPO, and TNF-alpha immunostaining. Scale bar = 200 μm. i Quantification of CD14+, CD19+, CD68+, and TNF-alpha+ IHC stained tissues. The rhEGF was used as a positive control. Results are presented as mean ± standard error of the mean; n = 8 for each group. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 vs vehicle control group