Table 1.

Main findings from trans-ethnic EWAS meta-analyses for 13 replicated DMPs

				Our study discovery		Sample size by DNAm array		Replication GS/CATHGEN/HyperGEN		Combined discovery and replication
DMP	Chr	Position (hg38)	Gene	Effect	p	450K	EPIC 850 K	Effect	p	Effect	p
cg13235761^	1	203,592,452		− 37.61	4.33E−06	3048	2378	− 25.28	5.08E−05	− 29.81	1.88E−09
cg26099045^*	2	64,064,666		14.82	5.74E−06	3050	2378	11.24	1.01E−04	12.81	3.26E−09
cg04428662^Ω*	4	2,932,461	MFSD10	− 30.84	3.21E−06	3049	2378	− 34.94	3.43E−07	− 32.82	5.51E−12
cg23174201^*	5	151,674,695	SPARC	− 35.83	5.10E−06	3050	2378	− 34.87	1.72E−07	− 35.27	4.02E−12
cg17170437	6	44,229,461	SLC29A1	− 47.62	1.96E−06	N/A	2378	− 18.62	1.49E−04	− 24.24	3.80E−08
cg14871770	10	96,658,622	CYP2C9, CYPC19	− 53.12	1.98E−06	N/A	2378	− 25.87	1.70E−04	− 33.36	1.23E−08
cg02157636	11	68,709,367	TESMIN	− 53.21	2.15E−06	N/A	2378	− 27.25	1.14E−05	− 33.33	8.58E−10
cg26039141^Ω	11	75,402,116	RPS3	− 39.14	3.40E−06	3050	2378	− 33.42	1.78E−05	− 36.06	2.90E−10
cg22593432^*	13	32,001,768		− 29.91	1.54E−07	3050	2378	− 17.66	1.79E−04	− 22.64	4.61E−10
cg11789371^*	14	102,085,048	HSP90AA1	− 35.40	4.44E−06	3050	2378	− 22.66	3.58E−04	− 27.80	1.41E−08
cg05796561	18	57,128,273		− 45.24	2.96E−06	N/A	2378	− 22.91	1.69E−04	− 29.24	1.41E−08
cg17944885^Ω*	19	12,114,920	ZNF20, ZNF788P	− 32.71	1.41E−09	3048	2378	− 16.34	5.67E−07	− 20.72	1.24E−13
cg15787712^	19	13,837,429	LOC284454, MIR23	− 37.60	6.00E−09	3050	2378	− 28.65	2.06E−05	− 33.30	9.01E−13

p-value for replication < 6.4E−04 (Bonferroni correction for 78 DMPs tested). Four of the 13 DMPs that replicated were non-450K probes (cg17170437, cg14871770, cg02157636, cg05796561). Results from combined discovery and replication are also shown

GS Generation Scotland, N/A not applicable

^cis-meQTL from the BIOS QTL [36, 37]

ΩExpression quantitative trait methylation (eQTM) data from the BIOS QTL (enrichment p-value <0.01) [36, 37]

*cis-meQTL in the Framingham Heart Study [38]