TABLE 3.
Variable | Anxiety NOS vs. no anxiety OR (95% CI) | P | Anxiety NOS vs. DSM Anxiety OR (95% CI) | P | DSM anxiety vs. no anxiety OR (95% CI) | P |
---|---|---|---|---|---|---|
Demographic, clinical and global cognitive characteristics measured in total sample (n = 156) | ||||||
Sex a | 2.44 (1.02–5.85) | 0.046* | 0.83 (0.32–2.15) | 0.696 | 2.95 (1.37–6.35) | 0.006** |
Age | 0.98 (0.93–1.03) | 0.467 | 1.01 (0.96–1.07) | 0.634 | 0.97 (0.93–1.01) | 0.967 |
SMMSE b | 1.02 (0.76–1.37) | 0.879 | 0.69 (0.47–1.02) | 0.065 | 1.48 (1.06–2.07) | 0.020* |
PD‐CRS b | 0.98 (0.95–1.02) | 0.289 | 0.99 (0.95–1.03) | 0.590 | 0.99 (0.96–1.02) | 0.604 |
HAM‐D b | 1.28 (1.14–1.44) | <0.001*** | 0.86 (0.77–0.95) | 0.003** | 1.50 (1.32–1.70) | <0.001*** |
HAM‐A b | 1.27 (1.13–1.42) | <0.001*** | 0.87 (0.78–0.97) | 0.009** | 1.46 (1.30–1.65) | <0.001*** |
PDQ‐8 b | 1.31 (1.06–1.61) | 0.013* | 0.89 (0.72–1.10) | 0.291 | 1.47 (1.21–1.78) | <0.001*** |
MDS‐UPDRS Total b , c | 1.75 (0.71–4.32) | 0.221 | 0.65 (0.24–1.76) | 0.369 | 2.70 (1.19–6.14) | 0.017* |
MDS‐UPDRS‐I b , c | 4.24 (1.70–10.57) | 0.002** | 0.61 (0.22–1.68) | 0.340 | 6.95 (2.95–16.29) | <0.001*** |
MDS‐UPDRS‐II b | 0.41 (0.17–1.03) | 0.059 | 0.95 (0.87–1.03) | 0.222 | 1.07 (1.00–1.15) | 0.061 |
MDS‐UPDRS‐III b | 0.99 (0.95–1.04) | 0.719 | 0.97 (0.92–1.02) | 0.217 | 1.02 (0.99–1.07) | 0.235 |
MDS‐UPDRS‐IV b | 1.38 (1.15–1.64) | <0.001*** | 1.19 (1.01–1.42) | 0.044* | 1.15 (0.97–1.37) | 0.108 |
Years education b | 0.96 (0.87–1.06) | 0.404 | 0.94 (0.84–1.05) | 0.290 | 1.02 (0.93–1.12) | 0.683 |
LEDD b | 1.00 (1.00–1.00) | 0.054 | 1.00 (1.00–1.00) | 0.018* | 1.00 (1.00–1.00) | 0.383 |
Psychiatric characteristics measured in subsample (n = 82) | ||||||
PAS b | 1.18 (1.02–1.36) | 0.024* | 0.92 (0.81–1.05) | 0.224 | 1.28 (1.14–1.43) | <0.001*** |
Persistent anxiety b | 1.28 (1.03–1.60) | 0.030* | 0.91 (0.73–1.13) | 0.382 | 1.41 (1.20–1.66) | <0.001*** |
Episodic anxiety b | 1.52 (1.02–2.26) | 0.040* | 0.83 (0.58–1.19) | 0.311 | 1.83 (1.36–2.46) | <0.001*** |
Avoidance behavior b | 1.22 (0.77–1.92) | 0.386 | 0.79 (0.51–1.23) | 0.298 | 1.54 (1.14–2.08) | 0.005** |
LSAS b | 1.04 (1.01–1.08) | 0.024* | 0.98 (0.95–1.01) | 0.329 | 1.06 (1.03–1.09) | <0.001*** |
Fear or anxiety b | 1.07 (1.00–1.15) | 0.044* | 0.96 (0.90–1.02) | 0.212 | 1.12 (1.06–1.18) | <0.001*** |
Avoidance behavior b | 1.06 (0.98–1.13) | 0.139 | 0.96 (0.89–1.02) | 0.199 | 1.10 (1.05–1.16) | <0.001*** |
SAS b | 0.18 (0.29–1.06) | 0.058 | 0.95 (0.83–1.09) | 0.477 | 1.21 (1.09–1.35) | <0.001*** |
Univariate multinomial logistic regressions were conducted to compare current DSM‐IV Anxiety, Anxiety NOS and no anxiety disorder groups. Odds ratios (OR) and 95% confidence intervals (CI) are presented.
Male was the reference category.
Adjusted for age and sex.
Scores dummy‐coded using median splits.
P < 0.05.
P < 0.01.
P < 0.001.
SMMSE, Standardized Mini Mental State Examination; PD‐CRS, Parkinson's Disease Cognitive Rating Scale; HAM‐D, Hamilton Depression Rating Scale; HAM‐A, Hamilton Anxiety Rating Scale; PDQ‐8, Parkinson's Disease Questionnaire; MDS‐UPDRS, Movement Disorder Society Unified Parkinson's Disease Rating Scale; LEDD, levodopa equivalent daily dose; PAS, Parkinson's Anxiety Scale; LSAS, Liebowitz Social Anxiety Scale; SAS, Starkstein Apathy Scale.