Skip to main content
. 2021 Mar 24;41(4):e00627-20. doi: 10.1128/MCB.00627-20

FIG 1.

FIG 1

SHOC2 domains, sequence, and structural features. (A) Full-length SHOC2 (NCBI RefSeq NP_031399.2), depicting amino acid (AA) segments corresponding to domain regions and conserved leucine-rich repeats (LRRs). Conserved segments of SHOC2 from primary sequence analysis of several SHOC2 orthologs (COBALT) are annotated in red. (B) Primary sequence analysis of highly conserved SHOC2 LRRs (UniProtKB no. Q9UQ13-1) with consensus sequence logo (WebLogo v2.8.2) and sequence alignment (MAFFT v7.31). The canonical highly conserved leucine-rich repeat motif [LXXLXLXXN(X)2L] is outlined in blue. (C) 3D modeling of SHOC2 (SWISS-MODEL; template 3b2d.1.A) with predicted flexible hinge indicated. The inset represents a rotated view, highlighting parallel beta sheets.