FIG 3.

SHOC2-regulated RAS effector pathways and dynamic functional interactions. Shown is a schematic pathway overview of SHOC2’s role in the MAPK/ERK pathway involving MRAS/PP1 holophosphatase complex (A), HUWE1/PSMC5/VCP (B), interactors that sequester SHOC2 from RAS (C), posttranslational modifications that result in SHOC2 degradation (D), and PIK3CA/p110α that mediates PI3K/AKT signaling (E). Direct SHOC2 interactors that result in diminished MAPK signaling are depicted in red, and those that enable MAPK signaling are in blue. Ubiquitin chains are represented in purple, and multivesicular bodies (MVB)/late endosome (LE) are indicated.