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LRRK2 domain structure. LRRK2 is a multidomain kinase with two enzymatic domains, a Roc GTPase and a serine-threonine kinase of the TKL family, linked by a COR domain. LRRK2’s N and C termini are composed of protein-protein interaction domains, including N-terminal armadillo (ARM), ankyrin (ANK), and LRR domains and a C-terminal WD40 domain. Indicated at the top are the seven known LRRK2 point mutations that drive autosomal dominant PD.
