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. 2021 Feb 23;41(3):e00590-20. doi: 10.1128/MCB.00590-20

FIG 3.

FIG 3

Expression of only the truncating mutations in preosteoblasts results in low bone mass. (A) Gross body weights of 10-week-old male Osx-Cre Recql4fl/+, Osx-Cre Recql4fl/K525A, Osx-Cre Recql4fl/G522Efs, and Osx-Cre Recql4fl/R347X mice. (B) Tibial length. (C) Trabecular bone volume. (D) Trabecular number. (E) Trabecular separation. (F) Representative images (axial plane) of reconstructed trabecular bone with color-coded quantitative mineralization from Osx-Cre Recql4 mutants. (G) Cortical thickness. (H) Periosteal perimeter. (I) Moment of inertia. (J) Mediolateral width. (K) Anteroposterior width. (L) Representative images (axial plane) of reconstructed cortical bone with color-coded quantitative mineralization from Osx-Cre Recql4 mutants. Data expressed as mean ± SEM; ordinary one-way ANOVA. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. fl/+, n = 9; fl/K, n = 6; fl/G, n = 7, fl/R, n = 7. Experiments were independently executed on separate cohorts, with results pooled for presentation. fl, floxed; K, K525A; G, G522Efs; R, R347X.