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. 2021 Apr 27;14:1647–1660. doi: 10.2147/JIR.S306883

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© 2021 Jin et al.

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Ac-SDKP inhibits TLR4 and RANKL signaling in NR8383 cells treated with SiO_2. (A) TRAP staining, Bar= 50 μm; (B) IF staining of TLR4, Bar=100 μm; (C) Protein expression of RANKL, RANK, OC-STAMP, AP-1, NFATc1, TRAF6, NF-κB, TLR4, MyD88, p-IκBα, TNF-α, and MMP-12 in NR8383 cells treated with SiO₂ and Ac-SDKP or not. Data are presented as the mean ± SD. n = 3 per group.