Table 1.
Clinical characteristics of the case series
| Case | Age (years) |
Previous pregnancies | Gestational Age (weeks) | Comorbidities | COVID-19 symptoms/signs | Symptoms/signs onset (days)* |
NP swab date (days)* |
PROM | Delivery mode | Indication for C-section | Weight (grams) | Neonatal sex | APGAR scores at 1’ ad 5’ | Placental swab | Neonatal nasopharyngeal swab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 28 | 1 | 37 | None | Cough, fever | +1 | +1 | No | Vaginal | / | 3120 | F | 9/9 | Negative | Positive** |
| 2 | 25 | 2 | 38 | β-thalassemia trait | Fever | −3 | 0 | No | C-section | Two previous C-sections | 3010 | F | 9/9 | Negative | Negative |
| 3 | 30 | 1 | 36 | None | Cough | −8 | −8 | No | Vaginal | / | 2390 | M | 9/9 | Negative | Negative |
| 4*** | 35 | 1 | 30 | None | Fever, rhinorrhea | −11 | 0 | Yes (27 weeks) | C-section | Twin pregnancy (dichorionic/diamniotic), one previous C-section | 1090 and 950 | F and M |
First twin: 5/9 Second twin: 5/9 |
Negative /Negative | Negative /Negative |
| 5 | 39 | 4**** | 32 | Chronic hypertension, severe obesity (BMI: 50), gestational diabetes, polyhydramnios | Rhinorrhea, cough and fever since about one month. At admittance: initial respiratory fatigue with interstitial pneumonia | −39 | −9 | No | C-section | Respiratory distress, two previous C-sections | 2100 | F | 8/9 | Negative | Negative |
| 6 | 32 | 1 | 40 | β-thalassemia trait | Asymptomatic | Not applicable | −6 | No | Vaginal | / | 3530 | M | 9/9 | Negative | Negative |
| 7 | 37 | 2 | 37 | None | Asymptomatic | Not applicable | −18 | No | C-section | Previous C-section and orthopedic contraindication (spondylolisthesis) | 2469 | F | 9/9 | Negative | Negative |
| 8 | 43 | 3 | 37 | Intrahepatic cholestasis of pregnancy | Fever, cough | −85 | −66 | No | C-section | Three previous C-sections and intrahepatic cholestasis of pregnancy | 3130 | M | 9/9 | Negative | Negative |
| 9 | 36 | 2 | 35 | None | Asymptomatic | Not applicable | −95 | No | C-section | Twin pregnancy (monochorionic/diaamniotic), oligohydramnios and previous C-section | 2160 and 2060 | F and F |
First twin: 6/6 Second twin: 8/9 |
Negative/Negative | Negative |
| 10 | 32 | 2 | 37 | None | Asymptomatic | Not applicable | −1 | No | C-section | Marginal placenta previa | 2700 | M | 9/9 | Negative | Negative |
*Day 0 is considered the day of the delivery
**In this case a maternal rectal swab was positive for SARS-Cov-2 suggesting a fecal contamination of the newborn during the vaginal labor
***SARS-CoV-2 infection was found at 27 weeks of gestational age
****A newborn died one month after birth because of causes unrelated to pregnancy (infectious disease)
NP, nasopharyngeal; BMI, Body Mass Index; C-section, cesarean section; IUGR, intrauterine growth restriction; PROM, prelabor rupture of membranes; F, female; M, male