Table 3.
Differential metabolic pathways (CT vs. LPS6). The results of enriched compounds after screening and metabolic pathway enrichment analysis (MPEA) between the CT and LPS6 groups are summarized in this table.
| Total in pathway | Expected | Hits | Raw P | ′ − log(p) | Holm P | FDR | Impact | Enriched compounds | |
|---|---|---|---|---|---|---|---|---|---|
| Biosynthesis of unsaturated fatty acids | 42 | 1.2882 | 5 | 0.007835 | 4.8492 | 0.63462 | 0.28969 | 0 | (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid Arachidonic acid Linoleic acid Palmitic acid Stearic acid |
| Pantothenate and CoA biosynthesis | 15 | 0.46006 | 3 | 0.009458 | 4.6609 | 0.75666 | 0.28969 | 0.07692 | Beta-alanine L-Cysteine Uracil |
| Glyoxylate and dicarboxylate metabolism | 16 | 0.49073 | 3 | 0.011394 | 4.4747 | 0.90014 | 0.28969 | 0.16666 | Glyceric acid Glycolic acid Isocitric acid |
| Aminoacyl-tRNA biosynthesis | 67 | 2.0549 | 6 | 0.014306 | 4.2471 | 1 | 0.28969 | 0.12498 | L-Arginine L-Cysteine L-Histidine L-Methionine L-Proline L-Tryptophan |
| Citrate cycle (TCA cycle) | 20 | 0.61341 | 3 | 0.021295 | 3.8493 | 1 | 0.30896 | 0.10345 | Fumaric acid Isocitric acid Oxoglutaric acid |
| Taurine and hypotaurine metabolism | 8 | 0.24536 | 2 | 0.022886 | 3.7772 | 1 | 0.30896 | 0.5 | L-Cysteine Taurine |
| Arginine and proline metabolism | 44 | 1.3495 | 4 | 0.042713 | 3.1532 | 1 | 0.49425 | 0.18368 | Citrulline Fumaric acid L-Arginine L-Proline |
Holm: Holm-Bonferroni method; FDR: false discovery rate.