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IL-6 improved the immune-suppressive effects of MDSCs. (a) Experimental diagram of MDSC extraction and IL-6 treatment. (b–e) RT-PCR was used to evaluate Arg1 and iNOS levels in MDSCs with or without IL-6 treatment. (f–i) Summary of the suppressive effect of MDSCs by coculture with CD8+ T cells and CD4+ T cells at 1 : 4 and 1 : 2 ratios. Mean ± SD, ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.005, and ∗∗∗∗P < 0.001. ns: no statistical significance.
