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. 2021 May 2;28(30):40507–40514. doi: 10.1007/s11356-021-14195-9

Table 1.

The binding scores for each compound into the two target enzymes of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and the main protease (Mpro)

Bioactive compounds SARS-CoV-2 RNA-dependent RNA polymerase SARS-CoV-2 main protease (Mpro)
2,2-Dimethyl-8-prenylchromene −5.6 −6.8
Artepillin C −5.9 −7.5
3-Prenyl cinnamic acid allyl ester −5.3 −6.2
Isocupressic acid −5.8 −6.4
13C-symphyoreticulic acid −5.7 −6.9
Ellagic acid −6.4 −7.5
Syringic acid −5.5 −5.6
Caffeic acid phenethyl ester −5.4 −7.0
p-Coumaric acid −5.3 −5.6
Hesperetin −6.3 −7.4
Naringenin −6.0 −6.5
Kaempferol −6.2 −7.8
Quercetin −6.1 −7.4
Chrysin −6.1 −7.2