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. 2021 May 1;12(5):437. doi: 10.1038/s41419-021-03708-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The heat map showed the major dysregulated stemness-associated lncRNAs in BCSCs derived from epithelial or mesenchymal MCF-7 cells. The red or green dots indicated upregulated or downregulated lncRNAs, respectively. Data are shown as relative fold changes (>2.0) of MCF-7/Twist vs MCF-7/Vector. B Lnc408 expressions were proved by qRT-PCR analysis in non-EMT and EMT BC cells (SKBr3 as a control group, *P < 0.05). C qRT-PCR was used to assess the expression levels of lnc408, CD44, and SOX2 in BC tissues (n = 50). D, E qRT-PCR was conducted to determine the abundances of lnc408 in BCSC derived from BC cell lines and clinical BC samples (**P < 0.01). F Lnc408 expression was determined by qRT-PCR in different passage of BCSCs (P1 to P3; **P < 0.01, ***P < 0.001). For qRT-PCR assays, all data are shown as means ± SD.