Table 2.

The effects of vitamin K2 supplementation on atherogenic indexes¹

Variables	Vitamin K2 group (n = 32)	Placebo group (n = 31)	Between group p-value3	Adjusted p-value4
Castelli index Ӏ2
After 12-week	3.29 ± 0.75	3.67 ± 0.91	0.073	0.333
Mean change from baseline	– 0.04 ± 0.45	0.02 ± 0.55	0.657	–
Within group P-value5	0.657	0.834	–	–
Triglycerides / HDL-C ratio
After 12-week	2.81 ± 1.94	3.74 ± 2.25	0.083	0.252
Mean change from baseline	−0.10 ± 0.71	− 0.01 ± 0.51	0.570	–
Within group P-value5	0.442	0.925	–	–
AC6, 7
After 12-week	−0.21 ± 0.45	0.02 ± 0.43	0.043	0.167
Mean change from baseline	−0.03 ± 0.25	0.01 ± 0.21	0.407	–
Within group P-value5	0.440	0.709	–	–
Castelli index ӀӀ8
After 12-week	1.69 ± 0.41	1.88 ± 0.54	0.132	0.264
Mean change from baseline	0.02 ± 0.30	0.07 ± 0.38	0.506	–
Within group P-value5	0.777	0.297	–	–
TyG-Index
After 12-week	8.88 ± 0.55	9.23 ± 0.69	0.029	0.084
Mean change from baseline	−0.14 ± 0.46	0.0005 ± 0.42	0.205	–
Within group P-value5	0.091	0.995	–	–
AIP
After 12-week	0.37 ± 0.27	0.51 ± 0.24	0.031	0.135
Mean change from baseline	−0.03 ± 0.15	0.003 ± 0.12	0.325	–
Within group P-value5	0.245	0.901	–	–
METS-IR
After 12-week	43.1 ± 8.42	45.2 ± 7.29	0.292	0.067
Mean change from baseline	−0.80 ± 2.24	0.15 ± 2.30	0.101	–
Within group P-value5	0.052	0.719	–	–
LCI7
After 12-week	1.91 ± 0.34	2.04 ± 0.43	0.194	0.315
Mean change from baseline	1.34 ± 0.57	1.54 ± 0.53	0.167	–
Within group P-value5	0.391	0.842	–	–

AC Atherogenic Coefficient, AIP Atherogenic Index of Plasma, LCI Lipoprotein Combine Index, METS-IR Metabolic Score for Insulin Resistance, TyG-Index Triglyceride glucose Index, HDL-C High-density lipoprotein cholesterol

¹Data are presented as mean ± SD

²Total cholesterol / HDL-C ratio

³Based on independent sample T-test

⁴Based on Analysis of Covariance (ANCOVA)

⁵Based on paired sample T-test

⁶Non-HDL-C / HDL-C ratio

⁷Natural log-transformed values are reported

⁸LDL-C/HDL-C ratio