Table 2.

Hub genes with degree ≥ 10 in DEGs between adult SR and NSR

Gene	Full name	Function
Mag	Guanylate-binding protein 1	Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus (By similarity). Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes
Ugt8a	2-Hydroxyacylsphingosine 1-beta-galactosyltransferase	Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system
Plp1	Myelin proteolipid protein	This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin
Kcna1	Potassium voltage-gated channel subfamily A member 1	Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability
Sox10	Transcription factor SOX-10	Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination
Fa2h	Fatty acid 2-hydroxylase	Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis