FIGURE 1.

Study aims and analysis flow chart. The main aims are illustrated in the top boxes, subaims and their implementation in the bottom. Aim I (orange) is to assess differences in treatments in the aging population and identify potential stratifiers for greater beneficial effects of statins, to achieve the aim we determined drug exposure and assess their differences, focusing on statins treatments. Aim II (green) is to evaluate the potential beneficial effects of statin use in the aging population on survival, Alzheimer's disease (AD) incidence and cognitive decline; to achieve the aim we used the matched cohort and the identified stratifiers, derived from Aim I