TABLE 4.
Characteristics by cognitive trajectory class of Symbol Digit Modalities Test (SDMT; n = 17,883)
| Class, N (%) | |||||||
|---|---|---|---|---|---|---|---|
| Baseline characteristics | Very high/stable 456 (2.6) | High/minor decline 3025 (16.9) | Medium/minor decline 4869 (27.2) | Medium‐low/minor decline 5002 (28.0) | Low/minor decline 3314 (18.5) | Very low/minor decline 1217 (6.8) | P‐value* |
| Age, years | <.001 | ||||||
| 65–69 a | 13 (2.9) | 106 (3.5) | 133 (2.7) | 119 (2.4) | 83 (2.5) | 29 (2.4) | |
| 65–74 | 371 (81.4) | 2166 (71.6) | 3096 (63.6) | 2718 (54.3) | 1363 (41.1) | 328 (27.0) | |
| 75–84 | 71 (15.6) | 739 (24.4) | 1567 (32.2) | 1998 (39.9) | 1650 (49.8) | 689 (56.6) | |
| ≥85 | 1 (0.2) | 14 (0.5) | 73 (1.5) | 167 (3.3) | 218 (6.6) | 171 (14.1) | |
| Sex | <.001 | ||||||
| Male | 130 (28.5) | 1034 (34.2) | 1971 (40.5) | 2370 (47.4) | 1673 (50.5) | 652 (53.6) | |
| Female | 326 (71.5) | 1991 (65.8) | 2898 (59.5) | 2632 (52.6) | 1641 (49.5) | 565 (46.4) | |
| Ethnicity | <.001 | ||||||
| Australian White | 372 (81.6) | 2532 (83.7) | 4198 (86.2) | 4386 (87.7) | 2887 (87.1) | 1,022 (84.0) | |
| US White | 59 (12.9) | 280 (9.3) | 324 (6.7) | 217 (4.3) | 118 (3.6) | 27 (2.2) | |
| Black | 12 (2.6) | 120 (4.0) | 166 (3.4) | 204 (4.1) | 167 (5.0) | 97 (8.0) | |
| Hispanic/Latino | 5 (1.1) | 50 (1.7) | 104 (2.1) | 125 (2.5) | 98 (3.0) | 52 (4.3) | |
| Other | 8 (1.8) | 43 (1.4) | 77 (1.6) | 70 (1.4) | 44 (1.3) | 19 (1.6) | |
| Education, years | <.001 | ||||||
| < 12 | 110 (24.1) | 896 (29.6) | 1849 (38.0) | 2418 (48.3) | 1916 (57.8) | 856 (70.3) | |
| 12–15 | 134 (29.4) | 943 (31.2) | 1478 (30.4) | 1468 (29.4) | 906 (27.3) | 254 (20.9) | |
| ≥16 | 212 (46.5) | 1186 (39.2) | 1542 (31.7) | 1116 (22.3) | 492 (14.9) | 107 (8.8) | |
| Randomization group | <0.001 | ||||||
| Aspirin group | 214 (46.9) | 1513 (50.0) | 2391 (49.1) | 2506 (50.1) | 1681 (50.7) | 603 (49.6) | |
| Placebo group | 242 (53.1) | 1512 (50.0) | 2478 (50.9) | 2496 (49.9) | 1633 (49.3) | 614 (50.4) | |
| Incident dementia | <.001 | ||||||
| Yes | 0 (0.0) | 9 (0.3) | 39 (0.8) | 101 (2.0) | 201 (6.1) | 188 (15.5) | |
| No | 456 (100.0) | 3016 (99.7) | 4830 (99.2) | 4901 (98.0) | 3113 (93.9) | 1029 (84.5) | |
| Median (inter‐quartile range) | |||||||
| Length of follow‐up, years | 4 (3‐5) | 4 (3‐5) | 3 (3‐5) | 3 (3‐5) | 3 (3‐5) | 3 (1‐5) | <.001 |
| Number of cognitive assessments | 4 (3‐4) | 3 (3‐4) | 3 (3‐4) | 3 (3‐4) | 3 (3‐4) | 3 (2‐4) | <.001 |
a
Only includes U.S. Black or Hispanic/Latino individuals, who were eligible to enroll from 65 years and over (all other individuals needed to be aged at least 70 years to be eligible).
*
P‐values were based on chi‐squared tests or Fisher's exact tests for categorical variables, and Kruskal‐Wallis H‐tests for length of follow‐up.
Note: The labels of the trajectory classes correspond to those shown in Figure 1D.