Table 2.
Subgroup analysis of overall survival
| Subgroups | No. of studies | Pooled HR (95% CI) | Heterogeneity | |
|---|---|---|---|---|
| I2 (%) | p value | |||
| Region | ||||
| Eastern | 11 | 2.164 (1.838–2.549) | 13.78 | 0.313 |
| Western | 3 | 1.867 (1.560–2.33) | 0 | 0.927 |
| Sample sizes | ||||
| < 200 | 7 | 2.473 (1.964–3.115) | 8.535 | 0.363 |
| ≥ 200 | 7 | 1.885 (1.649–2.154) | 0 | 0.878 |
| Stage | ||||
| I–III | 6 | 1.926 (1.627–2.281) | 19.71 | 0.285 |
| Include IV | 8 | 2.273 (1.872–2.761) | 0 | 0.682 |
| Treatment | ||||
| Surgery | 8 | 1.952 (1.680–2.268) | 13.5 | 0.325 |
| Chemotherapy | 3 | 2.223 (1.539–3.210) | 8.89 | 0.333 |
| Liver resection | 3 | 2.412 (1.778–3.273) | 0 | 0.658 |
| Cut-off value | ||||
| ≥ 0.1 | 8 | 1.924 (1.682–2.200) | 0 | 0.842 |
| < 0.1 | 6 | 2.382 (1.812–3.129) | 34.427 | 0.178 |
| Analysis method | ||||
| MV | 11 | 2.122 (1.798–2.503) | 22.476 | 0.229 |
| UV | 3 | 1.960 (1.564–2.455) | 0 | 0.958 |
CI confidence interval, HR hazard ratio, MV multivariate, UV univariate