Table 3.
Subgroup analysis of disease-free survival/progression-free survival
| Subgroups | No. of studies | Pooled HR (95% CI) | Heterogeneity | |
|---|---|---|---|---|
| I2 (%) | p value | |||
| Region | ||||
| Eastern | 8 | 1.793 (1.314–2.447) | 68.69 | 0.002 |
| Western | 1 | 1.600 (0.591–4.333) | 0 | 1 |
| Sample sizes | ||||
| < 200 | 5 | 2.646 (1.599–4.378) | 61.822 | 0.033 |
| ≥ 200 | 4 | 1.289 (1.075–1.546) | 0 | 0.584 |
| Stage | ||||
| I–III | 5 | 2.115 (1.297–3.449) | 76.339 | 0.002 |
| Include IV | 4 | 1.477 (1.044–2.089) | 40.865 | 0.167 |
| Treatment | ||||
| Surgery | 5 | 1.554 (1.077–2.244) | 68.94 | 0.012 |
| Chemotherapy | 2 | 4.448 (2.114–9.360) | 0 | 0.982 |
| Liver resection | 2 | 1.672 (1.212–2.308) | 0 | 0.84 |
| Cut-off value | ||||
| ≥ 0.1 | 4 | 2.269 (1.215–4.240) | 55.379 | 0.081 |
| < 0.1 | 5 | 1.613 (1.129–2.304) | 71.106 | 0.008 |
| Analysis method | ||||
| MV | 7 | 1.610 (2.214–2.135) | 61.628 | 0.016 |
| UV | 2 | 2.769 (1.024–7.490) | 57.907 | 0.123 |
CI confidence interval, HR hazard ratio, MV multivariate, UV univariate