Fig. 2.

Serum biomarkers and inflammatory parameters at study inclusion. a, b Clinical laboratory and inflammatory parameters of JIA patients (n = 266) were assessed at participating clinical centers upon study inclusion (baseline). Corresponding serum analyte levels were quantified by multiplexed bead array assay as well as ELISA (S100A8/A9, S100A12). b Parameters with significant differences are shown in relation to healthy control levels (range: light grey shading, 95th percentile: broken line). Data are presented as violin plots with individual values and were analyzed by Kruskal Wallis followed by Dunn’s multiple comparison test. * = p < 0.05, ** = p < 0.01, *** = p < 0.001, **** = p < 0.0001