Fig. 4.

Association of baseline serum biomarkers and inflammatory parameters with treatment escalation during the first 12 months. a Inflammatory parameters and serum biomarkers of JIA patients at study inclusion (n = 266) were analyzed according to whether or whether not receiving biological DMARDs during the first year. b, c Indicated parameters assessed at baseline performed (almost) significantly different when associated with eventual treatment escalation up to 12-month follow-up. Data are presented as violin plots with individual values or ROC (only significantly different parameters) and were analyzed by Mann-Whitney U test. * = p < 0.05, ** = p < 0.01