Table 1.
Literature review of myeloid sarcoma involving the gynecologic tract
| No | Authors, country, year of study | Number of cases (n) | Affected region | Concurrent AML | Treatment | % (n) | Duration of observation (months) |
|---|---|---|---|---|---|---|---|
| 1 [6] | B. Pathak et al., Canada, 2005 | 25 |
Cervix—76% (n = 19) Uterine corpus—8% (n = 2) External genital organs—4% (n = 1) ≥ 2 gynecologic sites—4% (n = 1) Not stated—8% (n = 2) |
48% (n = 12) | CT | 28 (7) | 7.7 |
| RT | 8 (2) | 5 | |||||
| SI | 8 (2) | 3 | |||||
| CT + RT | 24 (6) | 13.75 | |||||
| CT + SI | 8 (2) | 20.5 | |||||
| RT + SI | 4 (1) | 1.75 | |||||
| Without treatment | 16 (4) | < 1 | |||||
| 2 [40] | R.M. Kahn et al., USA, 2019 | 1 | ≥ 2 gynecologic sites (uterine corpus, fallopian tubes, left ovary) | Yes | CT + SI | 3 | |
| 3 [12] | G.Modi et al., India, 2004 | 1 | External genital organs (vagina) | No | Hypomethylating therapy with decitabine | > 4 | |
| 4 [41] | J.-A. Hernández et al., Spain, 2002 | 2 | Cervix, left mesosalpinx, ovaries | 100% (n = 2) | CT + SI + autoBMT | 10 | |
| External genital organs (vagina) | CT + autoBMT | 10 | |||||
| 5 [42] | M. Ucar, M. Guryildirim, Turkey, 2014 | 1 | Breast, cervix, uterus | Yes | CT | > 2 | |
| 6 [43] | M.G. Garcia et al., USA, Spain, 2006 | 11 |
Cervix—27.3% (n = 3) Ovary—18.2% (n = 2) Uterine corpus—9% (n = 1) External genital organs—9% (n = 1) ≥ 2 gynecologic sites—36.5% (n = 4) |
36.5% (n = 4) | CT | 64 (7) | 40 |
| RT | 9 (1) | 5 | |||||
| CT + alloBMT | 9 (1) | > 6 | |||||
| SI | 73 (8) | - | |||||
| 9 |
Cervix—11% (n = 1) Ovary—89% (n = 8) |
22% (n = 2) | CT | 33 (3) | 15 | ||
| CT + alloBMT | 11 (1) | 10 | |||||
| 7 [44] | S.C.H. Kim et al., France, 2010 | 1 | Cervix | No | CT + RT | > 72 | |
| 8 [45] | H. Gill et al., China, 2012 | 1 | Cervix, left pelvic cavity | No | CT | 16 | |
| 9 [7] | W. Gui et al., China, 2019 | 2 | Cervix, external genital organs (vagina), intrapelvic lymph nodes | No | SI + CT | 21 | |
| Cervix, uterus, intrapelvic lymph nodes | Yes | CT | 26 | ||||
| 10 [46] | A.S. Weingertner et al., France, 2009 | 1 | Cervix, intrapelvic lymph nodes | Yes | CT | > 3 | |
| 11 [47] | Y. Yu et al., China, 2015 | 1 | External genital organs (vulva, vagina), cervix | No | CT | 4 | |
| 12 [48] | H. Bao et al., China, 2019 | 1 | External genital organs | Yes | SI + CT + alloBMT | > 6 | |
CT chemotherapy, RT radiotherapy, SI surgical intervention, autoBMT autologous bone marrow transplantation, alloBMT allogeneic bone marrow transplantation