FIGURE 5.

Changes in subiliac lymph node (SiLN) and proper axillary lymph node (PALN) volumes after cisplatin (CDDP) administration using the lymphatic drug delivery system (LDDS). A, SiLN volume normalized to the value at day −7^T. SiLN volume at day 6^T was significantly smaller in the III(+CDDP) and IV(+CDDP) groups than in the IV group (two‐way ANOVA and Tukey’s test: *P <.05, III[+CDDP] vs IV; IV vs IV[+CDDP]). SiLN volume at day 9^T was significantly smaller in the III(+CDDP), IV(+CDDP), and V(+CDDP) groups than in the i.v. III(+CDDP) group (two‐way ANOVA and Tukey’s test: **P <.01, i.v. III[+CDDP] vs III[+CDDP], i.v. III[+CDDP] vs IV[+CDDP]; *P <.05, i.v. III[+CDDP] vs V[+CDDP]). The B‐mode ultrasound images show the maximal plane of the lymph node (LN). Edematous changes are indicated by yellow arrows. Scale bars: 1 mm. B, PALN volume normalized to the value at day −7^T. PALN volume at day 9^T was significantly smaller in the V(+CDDP) group than in the III group (two‐way ANOVA and Tukey’s test: *P <.05, III vs V[+CDDP]). Data are presented as the mean ± SEM (i.v. III[+CDDP], n = 6; III, n = 6; III[+CDDP], n = 7; IV, n = 6, IV[+CDDP]), n = 6; V[+CDDP], n = 4). The B‐mode ultrasound images show the maximal plane of the LN. Scale bars: 1 mm