FIGURE 7.

Low ZHX3 expression combined with high RGS2 expression predicts the best prognosis of patients with UCB. A, High expression of ZHX3 and low expression of RGS2 were examined by IHC in 1 UCB case (top), and low expression of ZHX3 and overexpression of RGS2 were examined by IHC in another UCB case (below). The correlation between the expression levels of ZHX3 and RGS2 was evaluated in 199 UCB tissues, and the results showed that ZHX3 expression levels are negatively correlated with RGS2. *P < .05. B, C, Further Kaplan‐Meier analysis revealed that patients with both low ZHX3 and high RGS2 expression had the best survival rate in the SYSUCC cohort (P < .0001). D, Graphical representation reveals a proposed model for the role and major mechanism of the ZHX3/RGS2/RhoA signaling pathway in regulating the progression of UCB cells