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. 2021 Mar 4;112(5):1878–1887. doi: 10.1111/cas.14844

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© 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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PD‐L1 regulates MET phosphorylation through PTP1B. A, B, Influence of PD‐L1 manipulation on PTP1B expression in A431 and HCC827. Cells were transfected with various concentrations of PD‐L1‐siRNA or control siRNA for 48 h, and western blot was used to analyze the changes of PD‐L1 and PTP1B expression in A431 (A) and HCC827 (B). C, Immunoprecipitation analysis of influence of PD‐L1 inhibition on PTP1B/MET association in A431. D, Effect of PTP1B inhibitor on PD‐L1‐mediated MET phosphorylation in A431. E, Influence of PD‐L1 inhibition on PTP1B mRNA expression in A431. F, Immunoprecipitation analysis of effect of PD‐L1 inhibition on PTP1B ubiquitination in A431. Quantitative data are presented as mean ± SD based on 3 biological replicates