TABLE 2.

Univariate and multivariate analysis of prognostic factors in gastric cancer

Variable	Overall survival
	Univariate analysis		Multivariate analysis
	Hazard ratio (95% CI)	P‐value	Hazard ratio (95% CI)	P‐value
Age (<70 y/≥70 y)	1.153 (0.886‐2.628)	.132
Sex (male/female)	0.683 (0.398‐1.198)	.172
Histological type (differentiated/undifferentiated)	0.763 (0.445‐1.302)	.320
pT (T1‐2/T3‐4)	4.539 (2.423‐9.274)	<.001
pN (N0/N1‐3)	3.868 (2.102‐7.686)	<.001
pStage (I + Ⅱ/III + Ⅳ)	5.940 (3.305‐11.33)	<.001	3.276 (1.71‐6.606)	<.001*
Lymphatic invasion (ly−/ly+)	2.248 (1.265‐4.211)	.008
Venous invasion (v−/v+)	3.664 (2.119‐6.553)	<.001	2.599 (1.437‐4.852)	.002*
CD103 (low/high)	0.240 (0.135‐0.415)	<.001	0.287 (0.139‐0.581)	<.001*
CD8 (low/high)	0.495 (0.289‐0.838)	.009	1.094 (0.561‐2.102)	.788
TLS (poor/rich)	0.329 (0.173‐0.587)	<.001	0.549 (0.283‐1.005)	.061

Abbreviations: CI, confidence interval; pN, pathological lymph node metastasis; pT, pathological T category; TLS, tertiary lymphoid structure.