TABLE 1.
Clinical Parameters of Study Population
| ID | Gender | Race | Age (years) | Weight (kg) | Day of CRRT | No. of prior doses of meropenem | Underlying Illness | Positive Microbiolgy Results | Urine output (ml/kg/h) | Mode of Renal Replacement | Other concurrent extracorporeal therapy | Dialysis/Replacement Fluid | Concurrent medications |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Female | Myanmese | 0.1 | 3.3 | 6 | 8 | Critical pertussis, MOF | NPA: Pertussis | 0 | CVVHDF | VA ECMO | Hemosol BO | Erythromycin, Amphotericin B, Rocuronium, Midazolam, Fentanyl, Omeprazole |
| 2 | Male | Chinese | 0.3 | 6 | 3 | 3 | Myocarditis, acute renal and liver failure | NPA: Influenza A | 0 | CVVH | VA ECMO | Hemosol BO | Ampicillin, Neomycin, Rocuronium, Midazolam, Fentanyl, Ranitidine, Oseltamivir, Dopamine, Mirlinone, Hydrocortisone |
| 3 | Female | Chinese | 0.1 | 2.6 | 6 | 2 | Postoperative complex cyanotic heart disease, prematurity, severe capillary leak | 0 | CVVH | Nil | Hemosol BO | Vancomycin, Fluconazole, Morphine, Dopamine, Epinephrine, Norepinephrine, Heparin | |
| 4 | Male | Chinese | 16 | 52.7 | 2 | 1 | Relapsed suprasellar germinoma post stem cell transplant | Blood culture: E. Coli (ESBL), Candida krusei ETT culture: A. baumanii | <0.1 | CVVHDF | Nil | PrismOCal | Acyclovir, Voriconazle, Ambisome, Caspofungin, Morphine, Midazolam, Omeprazole, Dopamine, Norepinephrine |
| 5 | Male | Chinese | 9.6 | 41.5 | 2 | 5 | Relapsed ALL post stem cell transplant, CMV pneumonitis | Blood: CMV PCR + NPA: Parainfluenza 1 | 0 | CVVH | Nil | Hemosol BO | Cotrimoxazole, Ciclosporin, Voriconazole, Ambisome, Cas pofungin, Acetaminophen, Midazolam, Omeprazole, Dopamine, Norepinephrine |
| 6 | Female | Malay | 13.8 | 29 | 18 | 2 | Pulmonary hemosiderosis with ARDS | BAL culture: S. maltophilia, A. baumanii | 0 | CVVHDF | VV ECMO | Hemosol BO | Ambisome, Anidulafungin, Morphine, Midazolam, Epinephrine, Tranexamic acid, Heparin |
| 7 | Female | Chinese | 1.8 | 10.3 | 6 | 4 | Streptococcus pneumonia with HUS | Blood culture: S. pneumoniae ETT culture: A. baumanii | 0 | CVVHDF | Nil | PrismOCal | Levofloxacin, Fluconazole, Fentanyl, Midazolam, Acetaminophen |
| 8 | Female | Japanese | 4.9 | 19 | 2 | 7 | EBV related HLH, MOF | Stool culture: E. coli (ESBL) | <0.1 | CVVH | Nil | PrismOCal | Doxycycline, Ambisome, Morphine, Midazolam, Acetaminophen, Dexamethasone, Tranexamic acid |
| 9 | Male | Malay | 18.9 | 56.3 | 8 | 3 | Postoperative Fontan | ETT culture: E. cloacae, A. baumanii | 0 | CVVHDF | VA ECMO | Hemosol BO | Morphine, Midazolam, Omeprazole, Epinephrine, Milrinone, Amiodarone, Sodium valproate, Heparin, Trenaxemic acid, Hydrocortisone |
BAL: Bronchoalveolar lavage; ETT: endotracheal tube; NPA: nasopharyngeal aspirate; EBV: Ebstein Barr virus; CMV: Cytomegalovirus; ESBL: Extended spectrum beta=lactamase; MOF: Multiorgan failure; ARDS: Acute respiratory distress syndrome; ALL: Acute lymphoblastic leukemia; HLH: Hemophagocytic lymphohistiocytosis; HUS: Hemolytic uremic syndrome; VA ECMO: Veno-arterial extra-corporeal membrane oxygenation; VV ECMO: Veno-venous extra-corporeal membrane oxygenation