Table 1:
Demographics and clinical characteristics of patients with and without shock resolution by 48 hours from enrollment.
| Variable | Shock resolution (n = 81) | Persistent shock (n = 147) | P-value |
|---|---|---|---|
| Demographics | |||
| Age, years (IQR) | 62 (52, 70) | 64 (55, 73) | 0.26 |
| Male, n (%) | 51 (63) | 77 (52) | 0.12 |
| Female, n (%) | 30 (37) | 70 (48) | |
| Race | |||
| Black, n (%) | 24 (30) | 45 (31) | 0.91 |
| Asian, n (%) | 2 (2) | 3 (2) | |
| White, n (%) | 48 (59) | 89 (61) | |
| Other, n (%) | 7 (9) | 9 (6) | |
| Ethnicity | |||
| Hispanic, n (%) | 5 (6) | 7 (5) | 0.64 |
| Past medical history | |||
| Diabetes, n (%) | 26 (32) | 54 (37) | 0.59 |
| Liver disease, n (%) | 8 (10) | 26 (18) | 0.12 |
| Renal disease, n (%) | 8 (10) | 26 (18) | 0.12 |
| Physiologic variables | |||
| Heart rate, beats per minute (IQR) | 94 (82, 107) | 102 (88, 115) | 0.01 |
| Respiratory rate, breaths per minute (IQR) | 20 (16, 24) | 21 (18, 26) | 0.12 |
| Cumulative vasopressor index (IQR) | 4 (3, 7.5) | 4 (4, 8) | 0.001 |
| Body mass index (IQR) | 28 (22, 36) | 28 (24, 34) | 0.22 |
| Laboratory values | |||
| White blood count, cells/mm3 (IQR) | 17 (12, 26) | 19 (11, 28) | 0.69 |
| Platelet count, cells/mm3 (IQR) | 178 (98, 246) | 132 (70, 204) | 0.01 |
| Creatinine, mg/dL (IQR) | 1.8 (1.2, 2.7) | 2.0 (1.3, 2.9) | 0.31 |
| Total Bilirubin, mg/dL (IQR) | 0.9 (0.5, 1.7) | 1.4 (0.6, 3.3) | 0.007 |
| Lactate, mmol/L (IQR) | 3.1 (2.0, 5) | 4.1 (2.7, 7) | 0.002 |
| Severity of Illness | |||
| SOFA score | 9 (7, 12) | 12 (10, 14) | <0.001 |
| Co-interventions | |||
| L-carnitine treatment | 55 (68) | 104 (71) | 0.65 |