Table 2:

Univariate and multivariate logistic regression model of metabolite concentrations at enrollment to predict the primary outcome

Variable+	Univariate odds ratio	Lower 95% CI	Upper 95% CI	Multivariate odds ratio	Lower 95% CI	Upper 95% CI
Valine*	1.93	1.40	2.67	1.49	1.05	2.11
Leucine*	1.61	1.18	2.19	--	--	--
Isoleucine	1.44	1.06	1.96	--	--	--
Propylene glycol	0.70	0.52	0.94	--	--	--
Methionine#	0.73	0.56	0.96	0.74	0.55	1.00
Phenylalanine	1.33	1.00	1.76	--	--	--

CI - Confidence interval; SOFA - Sequential Organ Failure Assessment score (at enrollment)

⁺Other significant variables retained in the multivariate model were SOFA score and heart rate.

^*FDR corrected p value ≤ 0.05.

^#Methionine was not a significant independent predictor but was maintained in the model due to p<0.10 per the a priori methods.