Table 3:
Univariate and multivariate logistic regression model of metabolite concentrations at 48 hours that differentiate patients with shock resolution versus persistent shock
| Variable | Univariate odds ratio | Lower 95% CI | Upper 95% CI | Multivariate odds ratio | Lower 95% CI | Upper 95% CI |
|---|---|---|---|---|---|---|
| Isoleucine* | 2.20 | 1.41 | 3.44 | 2.11 | 1.34 | 3.32 |
| Creatine* | 0.54 | 0.38 | 0.75 | 0.54 | 0.38 | 0.78 |
| Oxoisocaproate* | 1.94 | 1.33 | 2.81 | -- | -- | -- |
| Leucine | 1.74 | 1.24 | 2.45 | -- | -- | -- |
| Tyrosine | 1.81 | 1.27 | 2.59 | 1.87 | 1.28 | 2.73 |
| Valine | 1.81 | 1.27 | 2.56 | -- | -- | -- |
| Glucose | 1.60 | 1.15 | 2.23 | -- | -- | -- |
| Ornithine | 1.38 | 1.00 | 1.91 | -- | -- | -- |
CI - Confidence interval; SOFA - Sequential Organ Failure Assessment score (at enrollment)
*
FDR corrected p value ≤ 0.05.