Table 4.

Associations between baseline subgingival microbiota and periodontal disease progression at 5-year examination.

Subgingival OTU Label	Crude OR (95% CI)*	P-value	Adjusted OR (95% CI)*†	P-value
36 Microflora elevated in moderate/severe periodontal categories (CDC/AAP) at baseline‡
Fretibacterium fastidiosum	1.37 (1.17–1.60)	<.001	1.38 (1.18–1.62)	<.001
Tannerella forsythia (Socransky red complex)	1.39 (1.18–1.63)	<.001	1.40 (1.19–1.65)	<.001
Fretibacterium sp._oral_taxon_360	1.33 (1.13–1.56)	<.001	1.34 (1.14–1.58)	<.001
Fretibacterium sp._oral_taxon_359	1.39 (1.20–1.61)	<.001	1.41 (1.21–1.64)	<.001
Porphyromonas gingivalis (Socransky red complex)	1.38 (1.19–1.60)	<.001	1.40 (1.21–1.62)	<.001
Desulfobulbus sp._oral_taxon_041	1.30 (1.12–1.51)	<.001	1.31 (1.13–1.53)	<.001
Anaerolineae_[G-1] sp._oral_taxon_439	1.25 (1.08–1.44)	.003	1.27 (1.09–1.47)	.001
Treponema denticola (Socransky red complex)	1.36 (1.16–1.58)	<.001	1.36 (1.17–1.59)	<.001
Dialister pneumosintes	1.15 (0.99–1.35)	.07	1.17 (1.00–1.36)	.09
Peptostreptococcaceae_[XI][G-6] [Eubacterium]_nodatum	1.37 (1.18–1.58)	<.001	1.40 (1.20–1.62)	<.001
Treponema maltophilum	1.29 (1.11–1.51)	.001	1.31 (1.12–1.52)	<.001
Selenomonas sp._oral_taxon_134	1.20 (1.03–1.40)	.02	1.21 (1.04–1.41)	.03
Treponema socranskii	1.25 (1.06–1.47)	.007	1.27 (1.08–1.50)	.005
Fretibacterium sp._oral_taxon_362	1.33 (1.15–1.53)	<.001	1.35 (1.17–1.57)	<.001
Pseudoramibacter alactolyticus	1.13 (0.97–1.31)	.11	1.15 (0.98–1.34)	.08
Streptococcus constellatus	1.07 (0.92–1.25)	.36	1.08 (0.93–1.26)	.25
Porphyromonas endodontalis	1.51 (1.29–1.76)	<.001	1.51 (1.29–1.77)	<.001
Anaeroglobus geminatus	0.93 (0.80–1.09)	.35	0.93 (0.79–1.09)	.29
Veillonellaceae_[G-1] sp._oral_taxon_150	0.97 (0.83–1.14)	.73	0.98 (0.84–1.15)	.89
Prevotella intermedia (Socransky orange complex)	1.14 (0.98–1.32)	.09	1.15 (0.99–1.34)	.06
Bacteroidaceae_[G-1] sp._oral_taxon_272	1.17 (1.01–1.36)	.04	1.18 (1.02–1.37)	.03
Lachnospiraceae_[G-8] sp._oral_taxon_500	1.46 (1.26–1.69)	<.001	1.47 (1.27–1.71)	<.001
TM7_[G-1] sp._oral_taxon_349	1.16 (0.99–1.35)	.07	1.15 (0.99–1.35)	.09
Filifactor alocis	1.49 (1.29–1.73)	<.001	1.50 (1.30–1.74)	<.001
Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum	1.34 (1.16–1.55)	<.001	1.34 (1.16–1.54)	.003
Prevotella dentalis	1.25 (1.08–1.45)	.003	1.26 (1.08–1.46)	.003
TM7_[G-5] sp._oral_taxon_356	1.10 (0.95–1.29)	.21	1.10 (0.94–1.28)	.29
Veillonellaceae_[G-1] sp._oral_taxon_145	1.22 (1.05–1.41)	.009	1.23 (1.06–1.42)	.008
Prevotella oralis	1.03 (0.89–1.21)	.67	1.04 (0.89–1.22)	.64
Prevotella sp._oral_taxon_526	1.19 (1.03–1.38)	.02	1.22 (1.05–1.41)	.009
Johnsonella sp._oral_taxon_166	1.37 (1.19–1.58)	<.001	1.39 (1.20–1.60)	<.001
Prevotella baroniae	1.12 (0.96–1.30)	.15	1.12 (0.97–1.31)	.17
Fusobacterium nucleatum_subsp._vincentii (Socransky orange complex)	0.97 (0.83–1.13)	.68	0.97 (0.83–1.13)	.62
Fretibacterium sp._oral_taxon_361	1.21 (1.05–1.39)	.009	1.21 (1.05–1.40)	.005
Parvimonas micra (Socransky orange complex)	1.05 (0.90–1.23)	.54	1.05 (0.90–1.23)	.47
Fretibacterium sp._oral_taxon_358	1.17 (1.02–1.36)	.03	1.18 (1.02–1.36)	.02
16 Microflora elevated in none/mild periodontal categories (CDC/AAP) at baseline‡
Microbacterium flavescens	0.97 (0.83–1.13)	.67	0.97 (0.83–1.14)	.62
Sphingomonas sp._oral_taxon_006	0.87 (0.74–1.02)	.09	0.88 (0.75–1.03)	.09
Porphyrobacter tepidarius	0.85 (0.73–1.00)	.05	0.86 (0.73–1.01)	.05
Brevundimonas diminuta	0.89 (0.76–1.04)	.15	0.90 (0.76–1.05)	.12
Actinomyces naeslundii	0.82 (0.70–0.95)	.009	0.81 (0.70–0.95)	.01
Streptococcus oralis (Socransky yellow complex)	0.78 (0.66–0.91)	.002	0.77 (0.66–0.91)	.002
Capnocytophaga sp._oral_taxon_324	0.93 (0.79–1.09)	.35	0.92 (0.78–1.08)	.32
Actinomyces massiliensis	0.77 (0.66–0.90)	.001	0.76 (0.65–0.89)	.001
Haemophilus parahaemolyticus	0.99 (0.84–1.15)	.87	0.98 (0.84–1.15)	.95
Sphingomonas echinoides	0.87 (0.75–1.03)	.10	0.87 (0.74–1.03)	.11
Gemella haemolysans	1.00 (0.86–1.17)	.99	1.00 (0.86–1.17)	.72
Streptococcus sp._oral_taxon_056	0.94 (0.80–1.10)	.41	0.92 (0.79–1.08)	.37
Haemophilus parainfluenzae	0.83 (0.71–0.96)	.02	0.82 (0.70–0.96)	.01
Leptotrichia goodfellowii	1.00 (0.86–1.17)	.99	1.00 (0.86–1.17)	.80
Rothia aeria	0.87 (0.74–1.01)	.07	0.85 (0.73–1.00)	.07
Lautropia mirabilis	0.82 (0.70–0.95)	.01	0.80 (0.69–0.94)	.02

^*OR, odds ratio, and CI, confidence interval, are for a 1-standard deviation increment in CLR transformed OTU.

See Table 3 for standard deviations. Microbiota ordered according to relative abundance (highest to lowest) in overall cohort.

Bold indicates statistical significance, not corrected for multiple comparisons.

^†Adjusted for age, neighborhood SES, and self-rated health status at baseline.

^‡As reported in Genco et al.²⁵