Figure 4.

Limited efficacy of cabozantinib on c-Myc mouse liver tumours. (A) Study design. (B) Kaplan-Meier survival of pretreatment, vehicle-treated and cabozantinib-treated c-Myc mice. (C) Liver weight of pretreatment, vehicle-treated and cabozantinib-treated c-Myc mice. (D) Macroscopic and microscopic appearance of livers from pretreatment, vehicle-treated and cabozantinib-treated c-Myc mice. Magnification ×40; scale bar=500 µm. (E) Ki-67 (magnification ×200; scale bar=100 µm), CD34 (magnification ×200; scale bar=100 µm) and p-Erk (magnification ×100; scale bar=200 µm) staining in livers from c-Myc mice. Ki-67–positive cells were counted and quantified as proliferation index. CD34 and p-Erk staining were quantified and represented as the percentage of the positive staining area of the whole section area. Tukey–Kramer test: at least p<0.05. a, versus pretreatment; b, versus vehicle.