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. 2020 Nov 3;70(9):1746–1757. doi: 10.1136/gutjnl-2020-320716

Figure 7.

Figure 7

Combined cabozantinib and MLN0128 treatment has a potent antineoplastic effect in HCC lesions from c-Met/β-catenin mice. (A) Scheme of the experiment. (B) Survival curve of c-Met/β-catenin mice pretreated, treated with vehicle, cabozantinib, MLN0128 and cabozantinib/MLN0128. (C) Liver weight of pretreatment, vehicle-treated, MLN0128-treated, cabozantinib-treated and cabozantinib/MLN0128-treated c-Met/β-catenin mice. (D) Gross images and H&E staining of livers from pretreatment, vehicle-treated, MLN0128-treated, cabozantinib-treated and cabozantinib/MLN0128-treated c-Met/β-catenin mice. Magnification ×40; scale bar=500 µm. (E) Myc-tag (magnification ×40; scale bar=500 µm) and (F) Ki-67 (magnification ×100; scale bar=200 µm) staining in livers from c-Met/ β-catenin mice. Myc-tag staining was quantified and represented as the percentage of the positive staining area of the whole section area. Ki-67–positive cells were counted and quantified as proliferation index. Tukey–Kramer test: at least p<0.05. a, versus pretreatment; b, versus vehicle; c, versus MLN0128; d, versus cabozantinib. combo, combined cabozantinib/MLN0128 treatment.