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. 2020 Nov 3;70(9):1746–1757. doi: 10.1136/gutjnl-2020-320716

Figure 8.

Figure 8

Effect of combined cabozantinib and MLN0128 treatment on tumour microvascular density and putative target proteins in livers from c-Met/β-catenin mice. (A) CD34 (magnification ×200; scale bar=100 µm) and CD31 (magnification,×200; scale bar=100 µm) staining in livers from c-Met/β-catenin mice. (B) p-Akt (Ser473) (magnification ×100; scale bar=200 µm) and p-Erk (magnification, ×100; scale bar=200 µm) staining in livers from c-Met/β-catenin mice. Western blot analysis was performed to determine the levels of phosphorylated Vegfr2, phosphorylated c-Met, Akt/mTOR and MAPK (C), as well as proliferation and apoptosis markers (D) in c-Met/β-catenin mice. Cabo, Cabozantinib; CC3, cleaved caspase 3; combo, combined cabozantinib/MLN0128 treatment.