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. 2020 Nov 3;70(9):1746–1757. doi: 10.1136/gutjnl-2020-320716

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Effect of combined cabozantinib and anti-PD-L1 treatment in c-Met/β-catenin mice and Akt/c-Met mice. (A) Study design. (B) Liver weight of pretreatment-treated, vehicle/isotype IgG-treated, cabozantinib-treated, PD-L1-treated and cabozantinib/anti-PD-L1-treated c-Met/β-catenin mice. (C) Liver weight of pretreatment-treated, vehicle/isotype IgG-treated, cabozantinib-treated, PD-L1-treated and cabozantinib/anti-PD-L1-treated Akt/c-Met mice. (D-E) Survival curve of c-Met/β-Catenin and Akt/c-Met mice treated with vehicle/isotype IgG, Cabozantinib, PD-L1 and Cabozantinib/anti-PD-L1. Tukey–Kramer test: at least p<0.05. a, versus pretreatment; b, versus vehicle; c, versus anti-PD-L1. Cabo, cabozantinib; Comb, combined cabozantinib and anti-PD-L1 treatment; Pre, pretreatment.