FIGURE 6.

Intracranial mesenchymal tumor with FUS‐CREM fusion. A, A 4‐year‐old girl presented with fevers and headaches and was found to have a large circumscribed and heterogeneously‐enhancing mass in the left occipital region of the brain with significant peritumoral edema. After gross total resection, local tumor recurrence was seen on follow‐up imaging as multiple‐enhancing nodules at the periphery of the prior resection cavity. B, Histologic sections demonstrated a highly cellular neoplasm with both sheet‐like and papillary growth patterns composed of epithelioid to rhabdoid tumor cells with prominent nuclear pleomorphism and atypia. C, Chromosomal copy number plot demonstrates that the FUS‐CREM fusion was the result of an unbalanced translocation between chromosome 10p11.21 and chromosome 16p11.2. D, Schematic of the FUS‐CREM gene fusion. E, Sanger chromatogram following reverse‐transcription PCR of the FUS‐CREM fusion transcript composed of exons 1–5 of FUS linked with exons 7–8 of CREM