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. 2021 May 3;11:11. doi: 10.1186/s13395-021-00267-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — KEGG pathway enrichment analyses of DEGs and DEPs of the diaphragm in response to CMV. The 30 top-ranked KEGG pathways enriched by the DEGs of the diaphragm in a young rats and b old rats. c Comparative network analyses of the KEGG pathways of both young and old rats. d The 10 top-ranked KEGG pathways enriched by the DEPs of the diaphragm in old rats. OS: organismal system; Me: metabolism; EIP: environmental information processing; CP: cellular processes; HD: human diseases. Z-score is used as a hint or a prediction of the status of the enriched KEGG pathways. Negative z-score (in green) represents “inhibited” status, whereas positive z-score (in red) represents “activated” status of the KEGG pathways