Figure 1.

Enclysis is a CD4+ T cell engulfment process that leads to the deletion of regulatory T cells. Hepatocytes from non-cirrhotic donor livers, or from end stage disease explants, and hepatocellular carcinoma cells were all able to engulf CD4+ T cells by enclysis. T helper cells and Treg cells experience different fates inside hepatocytes, where T helper cells were preserved alive for hours or released and thus they survived enclytic capture, while Treg-containing vesicles quickly acidified.