Figure 3.

Targeting enclysis to restore immune regulation in autoimmune liver disease, transplantation, viral infection and liver cancer. Enclysis is a natural process with the potential to alter regulatory T cell frequencies specifically in the liver, and potentiate existing Treg therapies. We propose that enclysis inhibition may augment Treg abundance where most needed, to dampen overactive immune responses in autoimmunity or transplantation. Conversely, enclysis-enhancing compounds would aid local, transient elimination of Treg cells to jump-start exhausted antiviral or anti-tumor responses.